Injectable Hybrid Hydrogels, with Cell-Responsive Degradation, for Tumor Resection

Injectable Hybrid Hydrogels, with Cell-Responsive Degradation, for Tumor Resection

I am proud to announce that my paper “Injectable Hybrid Hydrogels, with Cell-Responsive Degradation, for Tumor Resection” has just been published by the journal ACS Applied Biomaterial, a journal of the American Chemical Society family.

In this paper – the result of three years of hard work and of the collaboration between the group of Prof. Luisa De Cola (Institut de Science et d’Ingeni√©rie Supramol√©culaires, CNRS) and Prof. Silvana Perretta (IRCAD France) – we report an injectable hydrogel-based material that can be employed to assist the endoscopic resection of early-stage gastric cancer.

The material is a nanocomposite poly(amidoamine)s-based hydrogel, and contains silica nanoshells in the covalent backbone so that they can release bioactive molecules on demand. This hydrogel is cost-effective and easily injectable in the submucosa layer of the stomach, where it immediately forms a stable submucosal fluid cushion. This can reduce the risk of perforation and bleeding during the minimally-invasive surgery, but its degraded in a few days after the surgery forming non-toxic degradation products that can be easily expelled from the body.

Link to the paper

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